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Weight & Metabolicpreclinical

5-Amino-1MQ

5-amino-1-methylquinolinium
Weight & Metabolic · CAS 71338-17-3
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Category
Weight & Metabolic
Evidence grade
D
PubMed records
3
Female-tagged
2
Sex-analysis
0
CAS
71338-17-3
D
Evidence grade D, Preclinical / animal evidence only across 3 indexed studies. No human trial data. How grades work →
Female evidence: None
5-Amino-1MQ: of 3 PubMed records, 2 are tagged as including female subjects and 0 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-21. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Overview

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule research compound, not a peptide, studied as an inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). Its compact quinolinium structure gives it a research-friendly profile as a probe of a single, well-defined enzymatic target.

In laboratory models 5-Amino-1MQ has been studied for its relationship to NNMT enzyme activity and the downstream consequences for cellular methylation balance. Researchers examining methyl-donor dynamics have used it as a research material to investigate S-adenosylmethionine turnover and NAD+ salvage biochemistry in vitro and in preclinical systems. Because NNMT sits at the intersection of methylation and NAD+ metabolism, the compound is useful for dissecting how these pathways connect.

What makes 5-Amino-1MQ a notable entry for a metabolic research catalog is the relative specificity of its studied target. Whether these mechanisms translate to female physiology remains an open research question; our evidence review tracks how many of the underlying studies included women.

Summary

5-Amino-1MQ is a small-molecule inhibitor of the enzyme NNMT investigated for metabolic and muscle effects. The evidence is limited to a small number of cell and rodent studies; there are no human trials and no female-specific data.

Evidence in women

Menstrual cycle
Unstudied
No studies examine menstrual cycle interactions.
Pregnancy & lactation
Unstudied
No pregnancy or lactation safety data exist.
Hormonal interactions
Unstudied
No data on reproductive-hormone interactions.
Perimenopause & menopause
Unstudied
No perimenopausal or menopausal data.
Sex differences
Unstudied
The few preclinical studies did not report sex-stratified outcomes; there is no human data.

Mechanism

Inhibits nicotinamide N-methyltransferase (NNMT), which is proposed to raise cellular NAD+ and SAM and alter adipocyte and muscle metabolism in preclinical models.

Reported dosing & routes

◐

We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)No established human dose; NNMT inhibition characterized in cell and rodent models only.
Routesoral
Female-specific dosingNot established

Contraindications: insufficient data to characterize

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

insufficient human data to characterize

5-Amino-1MQ reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

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Draw for 5-Amino-1MQ

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from 5-Amino-1MQ's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is 5-Amino-1MQ?

5-Amino-1MQ, also known as 5-amino-1-methylquinolinium, is a research compound in our weight metabolic category. 5-Amino-1MQ is a small-molecule inhibitor of the enzyme NNMT investigated for metabolic and muscle effects.

Is 5-Amino-1MQ studied in women?

5-Amino-1MQ: of 3 PubMed records, 2 are tagged as including female subjects and 0 carry a sex-analysis tag. We grade this none: no PubMed record for 5-Amino-1MQ is tagged as including female subjects, so its effects in women are effectively unstudied. That blank is the finding, not a safety signal, and we do not fill it with guesses.

Has 5-Amino-1MQ been studied during pregnancy or breastfeeding?

Unstudied. No pregnancy or lactation safety data exist. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does 5-Amino-1MQ have, and why?

5-Amino-1MQ carries evidence grade D. Preclinical / animal evidence only across 3 indexed studies. No human trial data.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for 5-Amino-1MQ?

No. A female-specific dose for 5-Amino-1MQ is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is 5-Amino-1MQ administered in research?

In the published literature, 5-Amino-1MQ is administered via oral. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for 5-Amino-1MQ?

Effects reported in the research literature include insufficient human data to characterize. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

What is the CAS number for 5-Amino-1MQ?

The CAS registry number for 5-Amino-1MQ is 71338-17-3. It is also referred to as 5-amino-1-methylquinolinium, NNMT inhibitor. Use it to confirm identity against a Certificate of Analysis.

How should 5-Amino-1MQ be stored and handled?

5-Amino-1MQ sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy 5-Amino-1MQ for research?

For laboratory research use, 5-Amino-1MQ is available from our research-use partner, Aurevena Research. Applying code research15 takes 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Buy 5-Amino-1MQ at Aurevena Research
Research-use supplier: 5-Amino-1MQ is available from our research-use vendor for laboratory use. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
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Citations (PMID)

39067875 · 33645410 · 35013352

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Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.