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Dihexa

PNB-0408
Cognitive
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Category
Cognitive
Evidence grade
D
PubMed records
17
Female-tagged
0
Sex-analysis
0
CAS
—
D
Evidence grade D, Preclinical / animal evidence only across 17 indexed studies. No human trial data. How grades work →
Female evidence: None
Dihexa: of 17 PubMed records, 0 are tagged as including female subjects and 0 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-21. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Overview

Dihexa is a small-molecule compound derived from angiotensin IV, developed as a stabilized oligopeptide analogue intended to survive in laboratory systems where the parent peptide degrades quickly. Its compact, modified structure gives it a research-friendly profile for studying signaling events downstream of the angiotensin IV pathway.

In cognition and neuroscience research models, dihexa has been studied for its association with hepatocyte growth factor (HGF) and its receptor c-Met, a signaling axis that has been characterized against processes of synaptogenesis and dendritic connectivity in preclinical systems. Researchers examining mechanisms of synapse formation have used dihexa as a research material to probe how HGF/c-Met activation relates to neural network models in vitro and in animal preparations.

What makes dihexa notable for a cognitive research catalog is the relative specificity of its proposed mechanism within a well-defined signaling pathway. Whether these mechanisms translate to female physiology remains an open research question; our evidence review tracks how many of the underlying studies included women. Supplied for in-vitro and laboratory research only.

Summary

Dihexa is an angiotensin IV-derived peptide studied preclinically for synapse formation and cognition via the HGF/c-Met system. All evidence is preclinical; there are no human trials and no female-specific data.

Evidence in women

Menstrual cycle
Unstudied
No studies examine menstrual cycle interactions.
Pregnancy & lactation
Unstudied
No pregnancy or lactation safety data exist.
Hormonal interactions
Unstudied
No data on reproductive- or thyroid-hormone interactions.
Perimenopause & menopause
Unstudied
No perimenopausal or menopausal data, despite interest in age-related cognition.
Sex differences
Unstudied
Preclinical studies to date used few or no female animals and did not report sex-stratified outcomes.

Mechanism

Proposed to potentiate hepatocyte growth factor (HGF)/c-Met signaling, promoting synaptogenesis in preclinical models.

Reported dosing & routes

◐

We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)No established human dose; cognitive effects shown in animal models.
Routesoral, subcutaneous
Female-specific dosingNot established

Contraindications: active malignancy (HGF/c-Met signaling, theoretical)

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

insufficient human data to characterize

Dihexa reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

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Draw for Dihexa

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from Dihexa's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is Dihexa?

Dihexa, also known as PNB-0408, is a research compound in our cognitive category. Dihexa is an angiotensin IV-derived peptide studied preclinically for synapse formation and cognition via the HGF/c-Met system.

Is Dihexa studied in women?

Dihexa: of 17 PubMed records, 0 are tagged as including female subjects and 0 carry a sex-analysis tag. We grade this none: no PubMed record for Dihexa is tagged as including female subjects, so its effects in women are effectively unstudied. That blank is the finding, not a safety signal, and we do not fill it with guesses.

Has Dihexa been studied during pregnancy or breastfeeding?

Unstudied. No pregnancy or lactation safety data exist. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does Dihexa have, and why?

Dihexa carries evidence grade D. Preclinical / animal evidence only across 17 indexed studies. No human trial data.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for Dihexa?

No. A female-specific dose for Dihexa is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is Dihexa administered in research?

In the published literature, Dihexa is administered via oral, subcutaneous. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for Dihexa?

Effects reported in the research literature include insufficient human data to characterize. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

How should Dihexa be stored and handled?

Dihexa sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy Dihexa for research?

Dihexa is not currently listed by our research-use partner, Aurevena Research, but their catalog carries related compounds. Code research15 applies 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Browse the Aurevena catalog
Research-use supplier: Dihexa isn't currently listed by our research-use vendor. Their catalog carries related compounds. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
Browse the catalog →

Citations (PMID)

29733881 · 25649658

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Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.