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Hexarelin

Examorelin
Performance & Muscle · CAS 140703-51-1
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Category
Performance & Muscle
Evidence grade
C
PubMed records
291
Female-tagged
97
Sex-analysis
2
CAS
140703-51-1
C
Evidence grade C, Early human data only (Phase 1 / small-n) across 291 indexed studies. How grades work →
Female evidence: Extrapolated
Hexarelin: of 291 PubMed records, 97 are tagged as including female subjects and 2 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-21. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Overview

Hexarelin is a synthetic hexapeptide belonging to the growth-hormone secretagogue class. Its compact six-residue structure gives it a stable, research-friendly profile that has made it a recurring tool compound in studies of the growth-hormone axis.

In preclinical and in-vitro models, hexarelin has been studied for its stimulation of growth-hormone release and, distinctly, for its activity in cardiac-tissue research, where investigators have examined its interactions independent of the growth-hormone pathway. Researchers characterizing secretagogue pharmacology have used it as a research material to probe how peptide agonists engage these signaling systems.

What makes hexarelin a useful entry for a performance and muscle-physiology catalog is the dual character of its studied mechanisms, spanning both endocrine and cardiovascular models. Whether these mechanisms translate to female physiology remains an open research question; our evidence review tracks how many of the underlying studies included women. Supplied for laboratory research use only.

Summary

Hexarelin is a synthetic growth-hormone secretagogue studied in short-term human pharmacology work on growth-hormone release and cardiovascular effects; it has never been approved. Some human studies included women, but the literature is early-stage and not sex-stratified.

Evidence in women

Menstrual cycle
Unstudied
GH secretion is estrogen-sensitive, but hexarelin response has not been mapped across cycle phases.
Pregnancy & lactation
Unstudied
No pregnancy or lactation safety data; GH-axis stimulation in pregnancy has not been evaluated.
Hormonal interactions
Unstudied
No controlled data on interactions with estrogen or contraceptives despite the known estrogen–GH link.
Perimenopause & menopause
Unstudied
No perimenopausal or menopausal study populations reported.
Sex differences
Unstudied
Women were included in some pharmacology studies, but outcomes were not systematically analyzed by sex.

Mechanism

A growth-hormone secretagogue acting at the ghrelin/GHS receptor (and CD36) to stimulate GH release and exert direct cardiovascular effects.

Reported dosing & routes

◐

We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)~1–2 µg/kg in short-term human GH and cardiovascular pharmacology studies; no approved therapeutic dose.
Routessubcutaneous, intravenous, intranasal
Female-specific dosingNot established

Contraindications: active malignancy (GH-axis stimulation, theoretical)

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

transient cortisol and prolactin increaseflushing

Hexarelin reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

1
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Draw for Hexarelin

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from Hexarelin's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is Hexarelin?

Hexarelin, also known as Examorelin, is a research compound in our performance muscle category. Hexarelin is a synthetic growth-hormone secretagogue studied in short-term human pharmacology work on growth-hormone release and cardiovascular effects; it has never been approved.

Is Hexarelin studied in women?

Hexarelin: of 291 PubMed records, 97 are tagged as including female subjects and 2 carry a sex-analysis tag. We grade this extrapolated: women appear in the record, but no study is tagged for a sex-specific analysis, so female-relevant conclusions are inferred from mixed or male data rather than measured in women. See our methodology.

Has Hexarelin been studied during pregnancy or breastfeeding?

Unstudied. No pregnancy or lactation safety data; GH-axis stimulation in pregnancy has not been evaluated. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does Hexarelin have, and why?

Hexarelin carries evidence grade C. Early human data only (Phase 1 / small-n) across 291 indexed studies.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for Hexarelin?

No. A female-specific dose for Hexarelin is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is Hexarelin administered in research?

In the published literature, Hexarelin is administered via subcutaneous, intravenous, intranasal. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for Hexarelin?

Effects reported in the research literature include transient cortisol and prolactin increase, flushing. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

What is the CAS number for Hexarelin?

The CAS registry number for Hexarelin is 140703-51-1. It is also referred to as Examorelin. Use it to confirm identity against a Certificate of Analysis.

How should Hexarelin be stored and handled?

Hexarelin sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy Hexarelin for research?

For laboratory research use, Hexarelin is available from our research-use partner, Aurevena Research. Applying code research15 takes 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Buy Hexarelin at Aurevena Research
Research-use supplier: Hexarelin is available from our research-use vendor for laboratory use. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
Buy now →

Citations (PMID)

25278975 · 28400207 · 9186261

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CJC-1295 with DAC: of 32 PubMed records, 2 are tagged as including female subjects and 0 carry a sex-analysis tag.

Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.