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Performance & Musclepreclinical

IGF-1 LR3

Long R3 IGF-1
Performance & Muscle
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Category
Performance & Muscle
Evidence grade
D
PubMed records
23
Female-tagged
14
Sex-analysis
0
CAS
—
D
Evidence grade D, Preclinical / animal evidence only across 23 indexed studies. No human trial data. How grades work →
Female evidence: None
IGF-1 LR3: of 23 PubMed records, 14 are tagged as including female subjects and 0 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-21. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Overview

IGF-1 LR3 is a long-acting analog of insulin-like growth factor 1, modified with an arginine substitution and an additional N-terminal peptide extension that together reduce its binding to regulatory proteins. These changes extend its activity relative to native IGF-1 and make it a widely used tool compound in cell-growth research.

In vitro and in preclinical systems, IGF-1 LR3 has been studied for anabolic and cell-growth signaling, and it is commonly used as a research material in cell-culture work where a stable, sustained growth-factor signal is needed. Researchers characterizing proliferation and growth-factor pathways have used it to model IGF receptor activity.

What makes IGF-1 LR3 a notable entry for a performance-physiology catalog is its extended half-life relative to the native molecule, which gives investigators a more durable signal to work with. Whether these mechanisms translate to female physiology remains an open research question; our evidence review tracks how many of the underlying studies included women. Supplied for laboratory research use only.

Summary

IGF-1 LR3 is a long-acting IGF-1 analog used mainly as a cell-culture reagent and, unapproved, for muscle growth. It is prohibited in sport; there are no controlled human efficacy trials and no female-specific data.

Evidence in women

Menstrual cycle
Unstudied
No studies examine menstrual cycle interactions.
Pregnancy & lactation
Unstudied
No pregnancy or lactation safety data exist.
Hormonal interactions
Unstudied
Estrogen influences the GH/IGF-1 axis, but no controlled interaction data exist for this analog.
Perimenopause & menopause
Unstudied
No perimenopausal or menopausal data.
Sex differences
Unstudied
Used chiefly as a reagent; no human sex-difference data.

Mechanism

An IGF-1 analog with reduced binding-protein affinity, extending its half-life and activity at the IGF-1 receptor.

Reported dosing & routes

◐

We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)No established human dose; used as a laboratory reagent, with unregulated athletic use.
Routessubcutaneous
Female-specific dosingNot established

Contraindications: active malignancy (IGF-1 signaling, theoretical); hypoglycemia risk

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

hypoglycemiainsufficient human safety data to fully characterize

IGF-1 LR3 reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

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Draw for IGF-1 LR3

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from IGF-1 LR3's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is IGF-1 LR3?

IGF-1 LR3, also known as Long R3 IGF-1, is a research compound in our performance muscle category. IGF-1 LR3 is a long-acting IGF-1 analog used mainly as a cell-culture reagent and, unapproved, for muscle growth.

Is IGF-1 LR3 studied in women?

IGF-1 LR3: of 23 PubMed records, 14 are tagged as including female subjects and 0 carry a sex-analysis tag. We grade this none: no PubMed record for IGF-1 LR3 is tagged as including female subjects, so its effects in women are effectively unstudied. That blank is the finding, not a safety signal, and we do not fill it with guesses.

Has IGF-1 LR3 been studied during pregnancy or breastfeeding?

Unstudied. No pregnancy or lactation safety data exist. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does IGF-1 LR3 have, and why?

IGF-1 LR3 carries evidence grade D. Preclinical / animal evidence only across 23 indexed studies. No human trial data.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for IGF-1 LR3?

No. A female-specific dose for IGF-1 LR3 is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is IGF-1 LR3 administered in research?

In the published literature, IGF-1 LR3 is administered via subcutaneous. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for IGF-1 LR3?

Effects reported in the research literature include hypoglycemia, insufficient human safety data to fully characterize. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

How should IGF-1 LR3 be stored and handled?

IGF-1 LR3 sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy IGF-1 LR3 for research?

For laboratory research use, IGF-1 LR3 is available from our research-use partner, Aurevena Research. Applying code research15 takes 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Buy IGF-1 LR3 at Aurevena Research
Research-use supplier: IGF-1 LR3 is available from our research-use vendor for laboratory use. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
Buy now →

Citations (PMID)

42395176

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Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.