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Noopept

GVS-111
Cognitive
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Category
Cognitive
Evidence grade
C
PubMed records
107
Female-tagged
9
Sex-analysis
1
CAS
—
C
Evidence grade C, Early human data only (Phase 1 / small-n) across 107 indexed studies. How grades work →
Female evidence: Extrapolated
Noopept: of 107 PubMed records, 9 are tagged as including female subjects and 1 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-21. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Overview

Noopept is a proline-containing dipeptide, structurally related to the racetam family, developed as a research compound for the neuroprotection and cognition literature. Its small peptide structure and stability made it a convenient material for laboratory work relative to larger neurotrophic proteins.

In preclinical models, noopept has been studied for its association with nerve-growth-factor and brain-derived neurotrophic factor expression, as well as antioxidant and neuroprotective signaling. Researchers examining memory models, neuroprotection, and neurotrophic pathways have used it as a primary research material.

For a cognitive catalog, noopept is notable for linking a simple dipeptide structure to neurotrophic-factor pathways, which makes it a useful tool for mechanism-focused studies. Whether these mechanisms translate the same way across female physiology remains an open research question; our evidence review tracks how many of the underlying studies included women.

Summary

Noopept (omberacetam) is a synthetic dipeptide nootropic developed in Russia and used there clinically for cognitive and asthenic complaints. Its human evidence is largely from the Russian literature with limited independent replication, and it is not analyzed for female-specific outcomes.

Evidence in women

Menstrual cycle
Unstudied
No study examined noopept across the menstrual cycle.
Pregnancy & lactation
Unstudied
No pregnancy or lactation safety data exist.
Hormonal interactions
Unstudied
No controlled data on reproductive- or thyroid-hormone interactions.
Perimenopause & menopause
Unstudied
No perimenopausal or menopausal data.
Sex differences
Unstudied
Russian clinical reports included women but were not analyzed by sex.

Mechanism

Proposed to enhance BDNF/NGF expression and provide neuroprotection; metabolized in part to a cycloprolylglycine-like compound.

Reported dosing & routes

◐

We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)Oral doses around 10–20 mg/day are described in the Russian literature; not approved outside those markets.
Routesoral
Female-specific dosingNot established

Contraindications: insufficient independently-verified data to characterize

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

irritabilityinsufficient rigorous safety data to fully characterize

Noopept reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

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Draw for Noopept

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from Noopept's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is Noopept?

Noopept, also known as GVS-111, is a research compound in our cognitive category. Noopept (omberacetam) is a synthetic dipeptide nootropic developed in Russia and used there clinically for cognitive and asthenic complaints.

Is Noopept studied in women?

Noopept: of 107 PubMed records, 9 are tagged as including female subjects and 1 carry a sex-analysis tag. We grade this extrapolated: women appear in the record, but no study is tagged for a sex-specific analysis, so female-relevant conclusions are inferred from mixed or male data rather than measured in women. See our methodology.

Has Noopept been studied during pregnancy or breastfeeding?

Unstudied. No pregnancy or lactation safety data exist. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does Noopept have, and why?

Noopept carries evidence grade C. Early human data only (Phase 1 / small-n) across 107 indexed studies.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for Noopept?

No. A female-specific dose for Noopept is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is Noopept administered in research?

In the published literature, Noopept is administered via oral. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for Noopept?

Effects reported in the research literature include irritability, insufficient rigorous safety data to fully characterize. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

How should Noopept be stored and handled?

Noopept sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy Noopept for research?

Noopept is not currently listed by our research-use partner, Aurevena Research, but their catalog carries related compounds. Code research15 applies 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Browse the Aurevena catalog
Research-use supplier: Noopept isn't currently listed by our research-use vendor. Their catalog carries related compounds. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
Browse the catalog →

Citations (PMID)

12596521 · 30295186

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Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.