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Cognitivepreclinical

P21 (P021)

P021
Cognitive
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Category
Cognitive
Evidence grade
D
PubMed records
17
Female-tagged
7
Sex-analysis
0
CAS
—
D
Evidence grade D, Preclinical / animal evidence only across 17 indexed studies. No human trial data. How grades work →
Female evidence: None
P21 (P021): of 17 PubMed records, 7 are tagged as including female subjects and 0 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-21. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Overview

P21 is a small synthetic peptide derived from a biologically active region of ciliary neurotrophic factor (CNTF), designed to retain the neurotrophic-signaling character of the parent protein in a more compact, research-friendly form. Its size and stability make it a convenient tool compound for laboratory work on neuronal growth and survival pathways.

In preclinical and in-vitro models, P21 has been studied for its relationship to neurogenesis and neurotrophic signaling, including pathways associated with brain-derived neurotrophic factor (BDNF) and the survival of developing neurons. Researchers examining hippocampal plasticity and neuronal differentiation have used it as a research material to probe how CNTF-linked mechanisms operate at the cellular level.

What makes P21 a useful entry for a cognitive and neurological catalog is that it isolates a defined neurotrophic mechanism in a peptide small enough to characterize cleanly. Whether these mechanisms translate to female physiology remains an open research question; our evidence review tracks how many of the underlying studies included women.

Summary

P21 (P021) is a small neurotrophic peptide mimetic derived from ciliary neurotrophic factor, studied preclinically for neurogenesis and Alzheimer's-related pathology. All evidence is preclinical; there are no human trials and no female-specific data.

Evidence in women

Menstrual cycle
Unstudied
No studies examine menstrual cycle interactions.
Pregnancy & lactation
Unstudied
No pregnancy or lactation safety data exist.
Hormonal interactions
Unstudied
No data on reproductive- or thyroid-hormone interactions.
Perimenopause & menopause
Unstudied
No perimenopausal or menopausal data, despite interest in age-related cognition.
Sex differences
Unstudied
Preclinical studies did not report sex-stratified outcomes.

Mechanism

Mimics a region of ciliary neurotrophic factor to promote neurotrophic signaling and reduce abnormal tau pathology in preclinical models.

Reported dosing & routes

◐

We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)No established human dose; effects shown in animal models.
Routessubcutaneous, oral
Female-specific dosingNot established

Contraindications: insufficient data to characterize

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

insufficient human data to characterize

P21 (P021) reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

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Draw for P21 (P021)

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from P21 (P021)'s research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is P21 (P021)?

P21 (P021), also known as P021, is a research compound in our cognitive category. P21 (P021) is a small neurotrophic peptide mimetic derived from ciliary neurotrophic factor, studied preclinically for neurogenesis and Alzheimer's-related pathology.

Is P21 (P021) studied in women?

P21 (P021): of 17 PubMed records, 7 are tagged as including female subjects and 0 carry a sex-analysis tag. We grade this none: no PubMed record for P21 (P021) is tagged as including female subjects, so its effects in women are effectively unstudied. That blank is the finding, not a safety signal, and we do not fill it with guesses.

Has P21 (P021) been studied during pregnancy or breastfeeding?

Unstudied. No pregnancy or lactation safety data exist. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does P21 (P021) have, and why?

P21 (P021) carries evidence grade D. Preclinical / animal evidence only across 17 indexed studies. No human trial data.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for P21 (P021)?

No. A female-specific dose for P21 (P021) is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is P21 (P021) administered in research?

In the published literature, P21 (P021) is administered via subcutaneous, oral. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for P21 (P021)?

Effects reported in the research literature include insufficient human data to characterize. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

How should P21 (P021) be stored and handled?

P21 (P021) sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy P21 (P021) for research?

P21 (P021) is not currently listed by our research-use partner, Aurevena Research, but their catalog carries related compounds. Code research15 applies 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Browse the Aurevena catalog
Research-use supplier: P21 (P021) isn't currently listed by our research-use vendor. Their catalog carries related compounds. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
Browse the catalog →

Citations (PMID)

36291618 · 27400746

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Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.