For laboratory and educational research use only. Not medical advice.
Women's Peptide Research
Ask Vera
Home  /  Database  /  Pinealon
Cognitivepreclinical

Pinealon

EDR
Cognitive
ASK VERA ABOUT THIS ↗BUY NOW ↗
Category
Cognitive
Evidence grade
D
PubMed records
18
Female-tagged
3
Sex-analysis
0
CAS
—
D
Evidence grade D, Preclinical / animal evidence only across 18 indexed studies. No human trial data. How grades work →
Female evidence: None
Pinealon: of 18 PubMed records, 3 are tagged as including female subjects and 0 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-21. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Overview

Pinealon is a short synthetic tripeptide (Glu-Asp-Arg, or EDR) classified among the Khavinson family of short-peptide bioregulators and used as a tool compound in neuroscience research. Its minimal three-residue structure is the basis for the peptide-bioregulator model, in which small peptides are proposed to influence cellular regulation directly.

In laboratory and preclinical systems, Pinealon has been studied for its modeled penetration into cells and cell nuclei, its influence on gene-expression regulation, and neuroprotective and antioxidant-related signaling. Investigators working with short-peptide bioregulators have used it as a research material to examine how compact peptide sequences interact with nucleic-acid and oxidative-stress pathways in vitro.

Supplied for in-vitro and laboratory research only, Pinealon is of interest to a neurological catalog because it represents the short-bioregulator class in a well-defined form. Whether these mechanisms translate to female physiology remains an open research question; our evidence review tracks how many of the underlying studies included women.

Summary

Pinealon is a short synthetic tripeptide (Glu-Asp-Arg / EDR) among the Khavinson 'short peptide bioregulators,' studied for neuroprotective effects. The evidence is preclinical (cell and animal models); there are no controlled human trials and no female-specific data.

Evidence in women

Menstrual cycle
Unstudied
No studies examine menstrual cycle interactions.
Pregnancy & lactation
Unstudied
No pregnancy or lactation safety data exist.
Hormonal interactions
Unstudied
No data on reproductive- or thyroid-hormone interactions.
Perimenopause & menopause
Unstudied
No perimenopausal or menopausal data.
Sex differences
Unstudied
Preclinical studies did not report sex-stratified outcomes.

Mechanism

A Glu-Asp-Arg tripeptide proposed to enter cells and influence gene expression and protein synthesis related to neuroprotection in preclinical models.

Reported dosing & routes

◐

We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)No established human dose; studied in cell and animal models.
Routesoral
Female-specific dosingNot established

Contraindications: insufficient data to characterize

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

insufficient human data to characterize

Pinealon reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

1
2
3

Draw for Pinealon

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from Pinealon's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is Pinealon?

Pinealon, also known as EDR, is a research compound in our cognitive category. Pinealon is a short synthetic tripeptide (Glu-Asp-Arg / EDR) among the Khavinson 'short peptide bioregulators,' studied for neuroprotective effects.

Is Pinealon studied in women?

Pinealon: of 18 PubMed records, 3 are tagged as including female subjects and 0 carry a sex-analysis tag. We grade this none: no PubMed record for Pinealon is tagged as including female subjects, so its effects in women are effectively unstudied. That blank is the finding, not a safety signal, and we do not fill it with guesses.

Has Pinealon been studied during pregnancy or breastfeeding?

Unstudied. No pregnancy or lactation safety data exist. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does Pinealon have, and why?

Pinealon carries evidence grade D. Preclinical / animal evidence only across 18 indexed studies. No human trial data.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for Pinealon?

No. A female-specific dose for Pinealon is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is Pinealon administered in research?

In the published literature, Pinealon is administered via oral. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for Pinealon?

Effects reported in the research literature include insufficient human data to characterize. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

How should Pinealon be stored and handled?

Pinealon sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy Pinealon for research?

For laboratory research use, Pinealon is available from our research-use partner, Aurevena Research. Applying code research15 takes 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Buy Pinealon at Aurevena Research
Research-use supplier: Pinealon is available from our research-use vendor for laboratory use. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
Buy now →

Citations (PMID)

33396470 · 24738258

Related peptides

Arginine VasopressinA
Arginine Vasopressin: of 12,241 PubMed records, 4,072 are tagged as including female subjects and 100 carry a sex-analysis tag.
BromantaneC
Bromantane: of 62 PubMed records, 16 are tagged as including female subjects and 1 carry a sex-analysis tag.
CerebrolysinB
Cerebrolysin: of 629 PubMed records, 172 are tagged as including female subjects and 0 carry a sex-analysis tag.
DavunetideB
Davunetide: of 102 PubMed records, 24 are tagged as including female subjects and 4 carry a sex-analysis tag.

Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.