For laboratory and educational research use only. Not medical advice.
Women's Peptide Research
Ask Vera
Home  /  Database  /  SNAP-8
Skin & Hairanecdotal

SNAP-8

Acetyl Octapeptide-3
Skin & Hair · CAS 868844-74-0
ASK VERA ABOUT THIS ↗BUY NOW ↗
Category
Skin & Hair
Evidence grade
E
PubMed records
0
Female-tagged
0
Sex-analysis
0
CAS
868844-74-0
E
Evidence grade E, No indexed studies found. Grade reflects absence of evidence, not evidence of absence. How grades work →
Female evidence: None
SNAP-8: of 0 PubMed records, 0 are tagged as including female subjects and 0 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-21. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Overview

Snap-8 (acetyl octapeptide-3) is a synthetic octapeptide modeled on the N-terminal region of SNAP-25, used as a tool compound in neuromuscular and dermal research. Its sequence is designed to mimic part of a native synaptic protein, giving it a defined structural rationale for laboratory study.

In vitro and in preclinical systems, Snap-8 has been studied for its modeled competition with SNAP-25 within the SNARE complex, the protein assembly that governs vesicle fusion and the release of the neurotransmitter acetylcholine. Investigators examining neuromuscular signaling and topical peptide science have used it as a research material to probe SNARE-complex dynamics.

Supplied for in-vitro and laboratory research only, Snap-8 is a relevant entry for a skin and hair research catalog because it isolates a specific step in vesicle-fusion signaling. Whether these mechanisms translate to female physiology remains an open research question; our evidence review tracks how many of the underlying studies included women.

Summary

SNAP-8 (acetyl octapeptide-3) is a synthetic cosmetic peptide marketed for topical 'expression-line' use. It has essentially no peer-reviewed clinical literature, our PubMed search returned no indexed studies under its standard names, so there is no efficacy, safety, or female-specific evidence to report.

Evidence in women

Menstrual cycle
Unstudied
No indexed studies of any kind, so no cycle data.
Pregnancy & lactation
Unstudied
No pregnancy or lactation safety data exist.
Hormonal interactions
Unstudied
No data on hormonal interactions.
Perimenopause & menopause
Unstudied
No perimenopausal or menopausal data.
Sex differences
Unstudied
With no indexed studies, no sex-difference data can exist.

Mechanism

An acetylated octapeptide modeled on the N-terminus of SNAP-25, proposed to reduce catecholamine release at the neuromuscular junction in a topical cosmetic context.

Reported dosing & routes

◐

We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)Used topically in cosmetic formulations; no established systemic dose and no clinical efficacy data.
Routestopical
Female-specific dosingNot established

Contraindications: insufficient data to characterize

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

topical cosmetic use; systemic effects not characterized

SNAP-8 reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

1
2
3

Draw for SNAP-8

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from SNAP-8's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is SNAP-8?

SNAP-8, also known as Acetyl Octapeptide-3, is a research compound in our skin hair category. SNAP-8 (acetyl octapeptide-3) is a synthetic cosmetic peptide marketed for topical 'expression-line' use.

Is SNAP-8 studied in women?

SNAP-8: of 0 PubMed records, 0 are tagged as including female subjects and 0 carry a sex-analysis tag. We grade this none: no PubMed record for SNAP-8 is tagged as including female subjects, so its effects in women are effectively unstudied. That blank is the finding, not a safety signal, and we do not fill it with guesses.

Has SNAP-8 been studied during pregnancy or breastfeeding?

Unstudied. No pregnancy or lactation safety data exist. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does SNAP-8 have, and why?

SNAP-8 carries evidence grade E. No indexed studies found. Grade reflects absence of evidence, not evidence of absence.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for SNAP-8?

No. A female-specific dose for SNAP-8 is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is SNAP-8 administered in research?

In the published literature, SNAP-8 is administered via topical. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for SNAP-8?

Effects reported in the research literature include topical cosmetic use; systemic effects not characterized. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

What is the CAS number for SNAP-8?

The CAS registry number for SNAP-8 is 868844-74-0. It is also referred to as Acetyl Octapeptide-3, Acetyl Glutamyl Heptapeptide-3. Use it to confirm identity against a Certificate of Analysis.

How should SNAP-8 be stored and handled?

SNAP-8 sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy SNAP-8 for research?

For laboratory research use, SNAP-8 is available from our research-use partner, Aurevena Research. Applying code research15 takes 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Buy SNAP-8 at Aurevena Research
Research-use supplier: SNAP-8 is available from our research-use vendor for laboratory use. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
Buy now →

Related peptides

ArgirelineD
Argireline: of 45 PubMed records, 7 are tagged as including female subjects and 0 carry a sex-analysis tag.
GHK-CuC
GHK-Cu: of 81 PubMed records, 0 are tagged as including female subjects and 0 carry a sex-analysis tag.
GLOW - GHK-Cu (50mg) / BPC-157 (10mg) / TB500·
Multi-ingredient blend, its female evidence is reviewed per ingredient, not for the combination.
KLOW - GHK-Cu (50mg) / KPV (10mg) / BPC-157 (10mg) / TB500·
Multi-ingredient blend, its female evidence is reviewed per ingredient, not for the combination.

Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.