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DSIP

Delta Sleep-Inducing Peptide
Longevity · CAS 62568-57-4
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Category
Longevity
Evidence grade
C
PubMed records
462
Female-tagged
75
Sex-analysis
4
CAS
62568-57-4
C
Evidence grade C, Early human data only (Phase 1 / small-n) across 462 indexed studies. How grades work →
Female evidence: Extrapolated
DSIP: of 462 PubMed records, 75 are tagged as including female subjects and 4 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-21. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Overview

DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first identified in studies of sleep-related neurochemistry. Its small, well-defined structure and endogenous origin give it a research-friendly profile as a tool compound in circadian and neuroendocrine investigation.

In preclinical and in-vitro systems, DSIP has been studied for its modulatory relationship to sleep-architecture models, hypothalamic-pituitary-adrenal (HPA) axis signaling, neurotransmitter balance, and stress-response pathways. Researchers examining circadian-rhythm regulation have also used it as a research material to characterize electrophysiological models of slow-wave activity and the neuroendocrine signals associated with sleep-wake cycling.

What makes DSIP a useful entry for a neuroendocrine research catalog is the breadth of pathways it touches while remaining a compact, endogenous sequence that is straightforward to work with. Whether these mechanisms translate to female physiology remains an open research question; our evidence review tracks how many of the underlying studies included women. Supplied for in-vitro and laboratory research only.

Summary

DSIP (delta sleep-inducing peptide) is a naturally occurring nonapeptide investigated for sleep, stress, and neuroendocrine effects. The human evidence is limited and largely dates to small studies from the 1980s; no modern trials and no female-specific analyses have been indexed.

Evidence in women

Menstrual cycle
Unstudied
Sleep and stress hormones vary across the cycle, but DSIP has not been studied by cycle phase.
Pregnancy & lactation
Unstudied
No pregnancy or lactation safety data exist.
Hormonal interactions
Unstudied
No controlled data on interactions with reproductive or thyroid hormones.
Perimenopause & menopause
Unstudied
No perimenopausal or menopausal sleep studies with DSIP.
Sex differences
Unstudied
The limited, dated human literature did not analyze outcomes by sex.

Mechanism

An endogenous nonapeptide that crosses the blood-brain barrier and is proposed to modulate sleep architecture, stress hormones, and circadian signaling; its precise receptor targets remain unclear.

Reported dosing & routes

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We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)No standardized human dose; small older studies used varied intravenous regimens.
Routesintravenous, subcutaneous
Female-specific dosingNot established

Contraindications: insufficient modern data to characterize

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

insufficient modern human data to characterize

DSIP reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

1
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Draw for DSIP

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from DSIP's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is DSIP?

DSIP, also known as Delta Sleep-Inducing Peptide, is a research compound in our longevity category. DSIP (delta sleep-inducing peptide) is a naturally occurring nonapeptide investigated for sleep, stress, and neuroendocrine effects.

Is DSIP studied in women?

DSIP: of 462 PubMed records, 75 are tagged as including female subjects and 4 carry a sex-analysis tag. We grade this extrapolated: women appear in the record, but no study is tagged for a sex-specific analysis, so female-relevant conclusions are inferred from mixed or male data rather than measured in women. See our methodology.

Has DSIP been studied during pregnancy or breastfeeding?

Unstudied. No pregnancy or lactation safety data exist. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does DSIP have, and why?

DSIP carries evidence grade C. Early human data only (Phase 1 / small-n) across 462 indexed studies.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for DSIP?

No. A female-specific dose for DSIP is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is DSIP administered in research?

In the published literature, DSIP is administered via intravenous, subcutaneous. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for DSIP?

Effects reported in the research literature include insufficient modern human data to characterize. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

What is the CAS number for DSIP?

The CAS registry number for DSIP is 62568-57-4. It is also referred to as Delta Sleep-Inducing Peptide. Use it to confirm identity against a Certificate of Analysis.

How should DSIP be stored and handled?

DSIP sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy DSIP for research?

For laboratory research use, DSIP is available from our research-use partner, Aurevena Research. Applying code research15 takes 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Buy DSIP at Aurevena Research
Research-use supplier: DSIP is available from our research-use vendor for laboratory use. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
Buy now →

Citations (PMID)

11437870 · 6145137

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Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.