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Epitalon

Epithalon
Longevity
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Category
Longevity
Evidence grade
E
PubMed records
212
Female-tagged
65
Sex-analysis
0
CAS
—
E
Evidence grade E, Only anecdotal or in-vitro reports found across 212 indexed sources. How grades work →
Female evidence: None
Epitalon: of 212 PubMed records, 65 are tagged as including female subjects and 0 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-17. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Overview

Epitalon, also spelled epithalon, is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, modeled on epithalamin, a peptide preparation originally derived from pineal-gland extract. Its very short structure gives it a research-friendly profile as a tool compound in cellular-aging investigation.

In laboratory systems, epitalon has been studied for its proposed influence on telomerase activity, telomere-length dynamics, pineal and melatonin-regulation models, and circadian gene expression. Much of this work has been conducted by a limited number of research groups, and the underlying mechanisms are not well characterized in rigorous, independently replicated preclinical models, so the compound is best understood as an exploratory research material rather than a well-established one.

What makes epitalon a notable catalog entry is its recurring use in aging- and telomere-related research questions despite that thin and largely low-quality evidence base. Whether its proposed mechanisms translate to female physiology remains an open research question; our evidence review tracks how many of the underlying studies included women. Supplied for in-vitro and laboratory research only.

Summary

Epitalon is a synthetic tetrapeptide based on the pineal peptide epithalamin, studied primarily by a single research group for aging- and telomerase-related claims. The human evidence is limited and largely low-quality, with no rigorous independent trials and no female-specific data.

Evidence in women

Menstrual cycle
Unstudied
No studies examine menstrual cycle interactions.
Pregnancy & lactation
Unstudied
No pregnancy or lactation safety data exist; absence of harm data is not evidence of safety.
Hormonal interactions
Unstudied
No data on estrogen, thyroid, or contraceptive interactions.
Perimenopause & menopause
Unstudied
Despite the pineal/aging framing, there is no menopause-specific data.
Sex differences
Unstudied
The limited available studies did not report sex-stratified outcomes.

Mechanism

Proposed to modulate pineal function and telomerase activity; mechanisms are not well characterized in rigorous, independently replicated models.

Reported dosing & routes

◐

We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)No established dose; reported in limited studies only (not advice).
Routessubcutaneous, intramuscular, intranasal
Female-specific dosingNot established

Contraindications: insufficient data to characterize

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

insufficient human data to characterize

Epitalon reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

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Draw for Epitalon

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from Epitalon's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is Epitalon?

Epitalon, also known as Epithalon, is a research compound in our longevity category. Epitalon is a synthetic tetrapeptide based on the pineal peptide epithalamin, studied primarily by a single research group for aging- and telomerase-related claims.

Is Epitalon studied in women?

Epitalon: of 212 PubMed records, 65 are tagged as including female subjects and 0 carry a sex-analysis tag. We grade this none: no PubMed record for Epitalon is tagged as including female subjects, so its effects in women are effectively unstudied. That blank is the finding, not a safety signal, and we do not fill it with guesses.

Has Epitalon been studied during pregnancy or breastfeeding?

Unstudied. No pregnancy or lactation safety data exist; absence of harm data is not evidence of safety. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does Epitalon have, and why?

Epitalon carries evidence grade E. Only anecdotal or in-vitro reports found across 212 indexed sources.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for Epitalon?

No. A female-specific dose for Epitalon is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is Epitalon administered in research?

In the published literature, Epitalon is administered via subcutaneous, intramuscular, intranasal. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for Epitalon?

Effects reported in the research literature include insufficient human data to characterize. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

How should Epitalon be stored and handled?

Epitalon sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy Epitalon for research?

For laboratory research use, Epitalon is available from our research-use partner, Aurevena Research. Applying code research15 takes 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Buy Epitalon at Aurevena Research
Research-use supplier: Epitalon is available from our research-use vendor for laboratory use. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
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Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.