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Weight & Metabolicapproved

Plecanatide

Trulance
Weight & Metabolic
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Category
Weight & Metabolic
Evidence grade
A
PubMed records
125
Female-tagged
22
Sex-analysis
0
CAS
—
A
Evidence grade A, Approved indication with 22 indexed studies that included female subjects. How grades work →
Female evidence: Extrapolated
Plecanatide: of 125 PubMed records, 22 are tagged as including female subjects and 0 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-21. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Overview

Plecanatide is a uroguanylin-analog peptide that acts as an agonist at the guanylate cyclase-C receptor on the intestinal lining. It was designed to mimic an endogenous signaling peptide, which gives it a defined, receptor-specific mechanism to study.

In research models, plecanatide has been studied for its association with intestinal fluid regulation and gut-signaling pathways mediated by cyclic GMP. Investigators examining gastrointestinal physiology and gut-brain signaling have used it as a research material within the GC-C agonist class.

For a metabolic and gastrointestinal catalog, plecanatide is notable for its receptor specificity, which supports isolated mechanistic study. Whether these mechanisms translate the same way across female physiology remains an open research question; our evidence review tracks how many of the underlying studies included women.

Summary

Plecanatide (Trulance) is an FDA-approved guanylate cyclase-C agonist for chronic idiopathic constipation and IBS with constipation, conditions that are more common in women. Registration trials enrolled predominantly women, but outcomes were not formally analyzed by sex.

Evidence in women

Menstrual cycle
Unstudied
Bowel symptoms can vary across the cycle, but plecanatide response has not been analyzed by cycle phase.
Pregnancy & lactation
Unstudied
Minimal systemic absorption is expected, but there are no adequate pregnancy or lactation studies.
Hormonal interactions
Unstudied
No controlled data on interactions with reproductive or thyroid hormones.
Perimenopause & menopause
Unstudied
No perimenopause- or menopause-specific analyses.
Sex differences
Unstudied
Chronic constipation and IBS-C are more prevalent in women and trials enrolled predominantly women, but outcomes were not formally analyzed by sex.

Mechanism

A uroguanylin analog that activates guanylate cyclase-C on the gut lining, increasing fluid secretion and transit.

Reported dosing & routes

◐

We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)3 mg once daily by mouth per the approved label.
Routesoral
Female-specific dosingNot established

Contraindications: children under 6 (serious dehydration risk in young pediatric patients); known or suspected mechanical GI obstruction

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

diarrhea

Plecanatide reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

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Draw for Plecanatide

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from Plecanatide's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is Plecanatide?

Plecanatide, also known as Trulance, is a research compound in our weight metabolic category. Plecanatide (Trulance) is an FDA-approved guanylate cyclase-C agonist for chronic idiopathic constipation and IBS with constipation, conditions that are more common in women.

Is Plecanatide studied in women?

Plecanatide: of 125 PubMed records, 22 are tagged as including female subjects and 0 carry a sex-analysis tag. We grade this extrapolated: women appear in the record, but no study is tagged for a sex-specific analysis, so female-relevant conclusions are inferred from mixed or male data rather than measured in women. See our methodology.

Has Plecanatide been studied during pregnancy or breastfeeding?

Unstudied. Minimal systemic absorption is expected, but there are no adequate pregnancy or lactation studies. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does Plecanatide have, and why?

Plecanatide carries evidence grade A. Approved indication with 22 indexed studies that included female subjects.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for Plecanatide?

No. A female-specific dose for Plecanatide is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is Plecanatide administered in research?

In the published literature, Plecanatide is administered via oral. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for Plecanatide?

Effects reported in the research literature include diarrhea. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

How should Plecanatide be stored and handled?

Plecanatide sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy Plecanatide for research?

Plecanatide is not currently listed by our research-use partner, Aurevena Research, but their catalog carries related compounds. Code research15 applies 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Browse the Aurevena catalog
Research-use supplier: Plecanatide isn't currently listed by our research-use vendor. Their catalog carries related compounds. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
Browse the catalog →

Citations (PMID)

37211380 · 35738724

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Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.