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Weight & Metabolicpreclinical

SLU-PP-332

ERR pan-agonist
Weight & Metabolic · CAS 1936422-49-3
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Category
Weight & Metabolic
Evidence grade
D
PubMed records
10
Female-tagged
0
Sex-analysis
0
CAS
1936422-49-3
D
Evidence grade D, Preclinical / animal evidence only across 10 indexed studies. No human trial data. How grades work →
Female evidence: None
SLU-PP-332: of 10 PubMed records, 0 are tagged as including female subjects and 0 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-21. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Overview

SLU-PP-332 is a small-molecule research compound, not a peptide, studied as a pan-agonist of the estrogen-related receptors (ERRalpha, ERRbeta, and ERRgamma), a group of nuclear receptors central to oxidative metabolism. Its defined receptor selectivity makes it a clean tool for probing this transcriptional axis.

In vitro and in preclinical systems, SLU-PP-332 has been studied for its influence on mitochondrial biogenesis, fatty-acid-oxidation enzyme activity, and the transcriptional regulation of oxidative-metabolism gene programs. Researchers investigating exercise-associated metabolic signaling and mitochondrial function have used it as a research material to model ERR-driven gene expression.

Supplied for in-vitro and laboratory research only, SLU-PP-332 is a notable catalog entry because it targets a transcriptional node of oxidative metabolism rather than a cell-surface receptor. Whether these mechanisms translate to female physiology remains an open research question; our evidence review tracks how many of the underlying studies included women.

Summary

SLU-PP-332 is a small-molecule pan-agonist of the estrogen-related receptors (ERRα/β/γ) studied as an 'exercise mimetic.' The evidence is entirely preclinical (cell and rodent models); there are no human trials and no female-specific data, despite the ERR family's links to estrogen-related signaling.

Evidence in women

Menstrual cycle
Unstudied
No studies examine menstrual cycle interactions.
Pregnancy & lactation
Unstudied
No pregnancy or lactation safety data exist.
Hormonal interactions
Unstudied
Estrogen-related receptors are named for structural, not hormonal, homology to estrogen receptors; no interaction data exist for this compound.
Perimenopause & menopause
Unstudied
No perimenopausal or menopausal data.
Sex differences
Unstudied
Preclinical studies to date did not report sex-stratified outcomes.

Mechanism

A pan-agonist of estrogen-related receptors (ERRα/β/γ) that upregulates oxidative metabolism and mitochondrial programs, mimicking some effects of exercise in preclinical models.

Reported dosing & routes

◐

We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)No established human dose; characterized in cell and rodent models only.
Routesoral
Female-specific dosingNot established

Contraindications: insufficient data to characterize

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

insufficient human data to characterize

SLU-PP-332 reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

1
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Draw for SLU-PP-332

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from SLU-PP-332's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is SLU-PP-332?

SLU-PP-332, also known as ERR pan-agonist, is a research compound in our weight metabolic category. SLU-PP-332 is a small-molecule pan-agonist of the estrogen-related receptors (ERRα/β/γ) studied as an 'exercise mimetic.' The evidence is entirely preclinical (cell and rodent models); there are no human trials and no female-specific data, despite the ERR family's links to estrogen-related signaling.

Is SLU-PP-332 studied in women?

SLU-PP-332: of 10 PubMed records, 0 are tagged as including female subjects and 0 carry a sex-analysis tag. We grade this none: no PubMed record for SLU-PP-332 is tagged as including female subjects, so its effects in women are effectively unstudied. That blank is the finding, not a safety signal, and we do not fill it with guesses.

Has SLU-PP-332 been studied during pregnancy or breastfeeding?

Unstudied. No pregnancy or lactation safety data exist. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does SLU-PP-332 have, and why?

SLU-PP-332 carries evidence grade D. Preclinical / animal evidence only across 10 indexed studies. No human trial data.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for SLU-PP-332?

No. A female-specific dose for SLU-PP-332 is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is SLU-PP-332 administered in research?

In the published literature, SLU-PP-332 is administered via oral. Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for SLU-PP-332?

Effects reported in the research literature include insufficient human data to characterize. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

What is the CAS number for SLU-PP-332?

The CAS registry number for SLU-PP-332 is 1936422-49-3. It is also referred to as ERR pan-agonist. Use it to confirm identity against a Certificate of Analysis.

How should SLU-PP-332 be stored and handled?

SLU-PP-332 sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy SLU-PP-332 for research?

For laboratory research use, SLU-PP-332 is available from our research-use partner, Aurevena Research. Applying code research15 takes 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Buy SLU-PP-332 at Aurevena Research
Research-use supplier: SLU-PP-332 is available from our research-use vendor for laboratory use. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
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Citations (PMID)

42024694

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Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.