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Hormonal & Reproductiveearly_human

Kisspeptin-10

KP-10
Hormonal & Reproductive
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Category
Hormonal & Reproductive
Evidence grade
C
PubMed records
410
Female-tagged
182
Sex-analysis
1
CAS
—
C
Evidence grade C, Early human data only (Phase 1 / small-n) across 410 indexed studies. How grades work →
Female evidence: Direct
Kisspeptin-10: of 410 PubMed records, 182 are tagged as including female subjects and 1 carry a sex-analysis tag.Counts reflect PubMed records as of 2026-07-17. “Female” uses the Female MeSH filter and “sex-analysis” the Sex Factors MeSH filter, automated proxies pending manual study-level review. Methodology →

Overview

Kisspeptin-10 is a ten-residue C-terminal fragment of the kisspeptin protein, the neuropeptide product of the KISS1 gene. This fragment retains the receptor-activating portion of the parent molecule, which is why it is a widely used tool compound in reproductive-axis research.

In preclinical and clinical research models, kisspeptin-10 has been studied for its ability to trigger GnRH release upstream of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), placing it at an early control point of the reproductive cascade. Researchers examining fertility, the GnRH axis, and hypothalamic amenorrhea have used it as a research material to probe how upstream signals shape downstream hormone output.

What makes kisspeptin-10 unusual for this database is that it has been studied directly in women within reproductive-medicine research, so its evidence base includes female physiology rather than leaving it entirely as an open question. Our evidence review tracks how that base is distributed across the underlying studies. Supplied for laboratory research use only.

Summary

Kisspeptin-10 is unusual for this database: it has been studied directly in women, in reproductive-medicine research on the GnRH axis, fertility, and hypothalamic amenorrhea.

Evidence in women

Menstrual cycle
Evidence
Kisspeptin signaling changes across the menstrual cycle, and its effects on LH release have been studied in women at different cycle phases.
Pregnancy & lactation
Evidence
Placental kisspeptin has been studied in pregnancy research; this is observational reproductive science, not a basis for use.
Hormonal interactions
Evidence
Directly upstream of the reproductive hormone axis (GnRH → LH/FSH); interactions with estrogen feedback are characterized.
Perimenopause & menopause
No evidence
Studied mostly in reproductive-age women; menopausal-specific data is limited.
Sex differences
Evidence
In the indexed literature, many studies included women and a smaller number reported female-specific reproductive outcomes, a genuinely female-relevant evidence base.

Mechanism

A fragment of the kisspeptin protein studied for triggering GnRH release upstream of LH and FSH in reproductive-axis research.

Reported dosing & routes

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We don't give dosing or medical advice. The figures below describe what was used in published research, not a recommendation. Decide with your clinician.

Reported range (literature)Investigated in controlled research settings; no established therapeutic dose.
Routesintravenous (research), subcutaneous (research)
Female-specific dosingNot established

Contraindications: not established outside research settings

Side effects

Reported in the research literature. Sex-specific incidence has not been separately analysed in the available records.

generally well tolerated in research doses; data limited

Kisspeptin-10 reconstitution calculator

Enter this vial's amount, the bacteriostatic water you add, and a target amount to get the concentration and the U-100 syringe units to draw. Handling arithmetic for research use, not a dose recommendation.

Reconstitution

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Draw for Kisspeptin-10

5
units on a U-100 insulin syringe
020406080100
U-100 insulin syringe — 1 mL = 100 units
That's 0.05 mL drawn to the 5-unit mark.
Concentration5 mg/mL (5,000 mcg/mL)
Volume to draw0.05 mL
Doses per vial40

Reference chart at 5 mg/mL

Target amountVolume (mL)U-100 units
100 mcg0.02 mL2
250 mcg0.05 mL5
500 mcg0.1 mL10
750 mcg0.15 mL15
1000 mcg0.2 mL20

Research-use arithmetic only. This tool converts a vial amount, diluent volume, and a target amount into a concentration and syringe draw for laboratory handling. It is not dosing guidance, a recommendation, or a claim of safety or efficacy, and it does not account for overfill, dead space, or peptide purity. Nothing here is medical advice. “U-100” means 100 units = 1 mL; confirm your syringe graduation before measuring. See the reconstitution & storage handbook for handling detail.

Frequently asked questions

Answers drawn only from Kisspeptin-10's research facts and, where reviewed, its sex-disaggregated evidence. Nothing here is medical advice, dosing, or a claim of safety or efficacy.

What is Kisspeptin-10?

Kisspeptin-10, also known as KP-10, is a research compound in our hormonal reproductive category. Kisspeptin-10 is unusual for this database: it has been studied directly in women, in reproductive-medicine research on the GnRH axis, fertility, and hypothalamic amenorrhea.

Is Kisspeptin-10 studied in women?

Kisspeptin-10: of 410 PubMed records, 182 are tagged as including female subjects and 1 carry a sex-analysis tag. We grade this direct female evidence: at least one record carries a sex-analysis tag, so some findings are drawn from women rather than borrowed from mixed or male data. See how we read the evidence.

Has Kisspeptin-10 been studied during pregnancy or breastfeeding?

Evidence. Placental kisspeptin has been studied in pregnancy research; this is observational reproductive science, not a basis for use. This is not a safety clearance or a recommendation. Vera, our research chat, deliberately hard-stops on pregnancy, breastfeeding, and trying-to-conceive questions rather than answer them.

What evidence grade does Kisspeptin-10 have, and why?

Kisspeptin-10 carries evidence grade C. Early human data only (Phase 1 / small-n) across 410 indexed studies.. Grades are derived from the research record, never hand-assigned; see how grades work.

Is there a female-specific dose for Kisspeptin-10?

No. A female-specific dose for Kisspeptin-10 is not established, and this site does not provide dosing or medical advice. Any figures we show describe what published research used, not a recommendation. Decide anything about use with a qualified clinician.

How is Kisspeptin-10 administered in research?

In the published literature, Kisspeptin-10 is administered via intravenous (research), subcutaneous (research). Reported dose ranges on the Dosing tab describe what studies used for laboratory research, not a protocol for people. We don't provide dosing.

What side effects have been reported for Kisspeptin-10?

Effects reported in the research literature include generally well tolerated in research doses; data limited. Sex-specific incidence has not been separately analysed in the available records, so these are not broken out for women.

How should Kisspeptin-10 be stored and handled?

Kisspeptin-10 sold for research is supplied as a lyophilized (freeze-dried) powder. Lyophilized peptides are generally kept cold and dry, at roughly -20°C for longer-term storage and 2-8°C short-term, protected from light. Once reconstituted they are typically refrigerated and used within a short window, avoiding repeated freeze-thaw cycles. This is general laboratory handling for research use only, not a directive for human use. Always follow the handling and purity details on the product's Certificate of Analysis.

Where can I buy Kisspeptin-10 for research?

For laboratory research use, Kisspeptin-10 is available from our research-use partner, Aurevena Research. Applying code research15 takes 15% off. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.

Buy Kisspeptin-10 at Aurevena Research
Research-use supplier: Kisspeptin-10 is available from our research-use vendor for laboratory use. Code research15 for 15% off, applied automatically at checkout. We may earn a commission when you purchase through this link, at no extra cost to you. Products are for laboratory research use only.
Buy now →

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Educational information for laboratory and research use only. Not medical advice, a recommendation, or a claim of safety or efficacy; no personal dosing. “Unstudied” means no qualifying study was found, not that a compound is safe or unsafe.